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Endocrine Abstracts

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ea0070aep860 | Thyroid | ECE2020

The natural history of benign thyroid nodules: 10 years follow-up

Ramundo Valeria , Grani Giorgio , Bruno Rocco , Costante Giuseppe , Meringolo Domenico , Puxeddu Efisio , Torlontano Massimo , Tumino Salvatore , Lucisano Giuseppe , Nicolucci Antonio , Filetti Sebastiano , Durante Cosimo

Background and Aim: The incidental detection of asymptomatic thyroid nodules (TNs) has increased over time. Over 90% of newly diagnosed TNs are either cytologically or sonographically benign. This study aimed to determine the frequency and magnitude of changes in TNs size over time.Methods: We performed a prospective, multicenter, observational study involving consecutive euthyroid patients with 1–4 asymptomatic, sonographically or cytological...
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ea0063p25 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Management of mitotane for advanced adrenocortical carcinoma: a survey in Italy

Puglisi Soraya , Saba Laura , Perotti Paola , Calabrese Anna , Basile Vittoria , Arnaldi Giorgio , Cannavo Salvatore , Stigliano Antonio , Canu Letizia , Loli Paola , Pivonello Rosario , Malandrino Pasqualino , Badalamenti Giuseppe , Torlontano Massimo , Della Casa Silvia , Scaroni Carla , Terzolo Massimo

Background and objective: Mitotane is the main option of treatment for advanced adrenocortical carcinoma (ACC). However, limited evidence is available regarding practical management of mitotane treatment and its eventual combination with chemotherapy or radiotherapy. The aim of the study is to do a survey on the use of mitotane for advanced ACC in expert Italian centers, analyzing data of the LYSOSAFE database.Methods: Retrospective analysis of patients ...
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ea0022p7 | Adrenal | ECE2010

Beneficial metabolic effects of surgical treatment in patients with an adrenal incidentaloma causing subclinical hypercortisolism

Chiodini Iacopo , Morelli Valentina , Salcuni Antonio Stefano , Vainicher Cristina Eller , Torlontano Massimo , Coletti Francesca , Iorio Laura , Cuttitta Antonello , Ambrosio Angelo , Vicentini Leonardo , Pellegrini Fabio , Copetti Massimiliano , Beck-Peccoz Paolo , Arosio Maura , Ambrosi Bruno , Trischitta Vincenzo , Scillitani Alfredo

Objective: In patients with adrenal incidentalomas (AI) the metabolic effect of the recovery of subclinical hypercortisolism (SH) is debated. The aim of this study was to determine the effect of the surgical and conservative approaches on the metabolic syndrome in AI patients with and without SH.Patients: One hundred and eight AI patients were studied; SH was diagnosed in the presence of >2 out of: urinary free cortisol >70 μg/24 h (193 nmol...
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ea0073aep642 | Thyroid | ECE2021

Estimating risk of recurrence of differentiated thyroid cancer patients: a real-world multicenter validation of the american thyroid association initial risk stratification and dynamic re-assessment after 5 years of follow-up.

Cera Gianluca , Grani Giorgio , Puxeddu Efisio , Arvat Emanuela , Pontecorvi Alfredo , Pio Lombardi Celestino , Torlontano Massimo , Chiara Zatelli Maria , Antonelli Alessandro , Tallini Giovanni , GRAZIA CASTAGNA MARIA , Fugazzola Laura , Filetti Sebastiano , Durante Cosimo

BackgroundMost Differentiated Thyroid Cancer (DTC) cases typically show indolent biological behavior and a low mortality rate. Various prognostic systems are used to assess disease recurrence risk, to tailor treatment and follow-up strategies. The initial Risk Stratification System (RSS) and dynamic Response to Therapy Re-stratification (RTR) system, recommended by the 2015 American Thyroid Association (ATA) Guidelines, are the most employed. Still, they...
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ea0063p24 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Management of adjuvant mitotane therapy for adrenocortical carcinoma: a survey in Italy

Puglisi Soraya , Calabrese Anna , Basile Vittoria , Pivonello Rosario , Ceccato Filippo , Scaroni Carla , Torlontano Massimo , Cannavo Salvatore , Arnaldi Giorgio , Stigliano Antonio , Malandrino Pasqualino , Saba Laura , Altieri Barbara , Casa Silvia Della , Perotti Paola , Berchialla Paola , De Filpo Giuseppina , Canu Letizia , Loli Paola , Reimondo Giuseppe , Terzolo Massimo

Background and objective: Mitotane is widely used as post-operative adjuvant treatment of adrenocortical carcinoma. However, the management of therapy is largely empirical. Mitotane monitoring is recommended but we do not know what impact target concentrations do have on patient outcome. The aim of the study is to evaluate its use in expert Italian centers, analyzing data of Lysosafe Online® database.Methods: Retrospective analysis of patients repor...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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